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KMID : 1137020130240010059
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Journal of Gynecologic Oncology
2013 Volume.24 No. 1 p.59 ~ p.65
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Establishment of a Korea HPV cohort study
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Lee Won-Chul
Lee Sae-Young
Koo Yu-Jin
Kim Tae-Jin
Hur Soo-Young
Park Jong-Sup
Hong Sung-Ran
Kim Sung-Soon
Kee Mee-Kyung
Rhee Jee-Eun
Lee Joo-Shil
Choi Ho-Sun
Cho Chi-Heum
Kim Ki-Tae
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Abstract
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We have designed a five-year multicentre prospective cohort study in women who are both human papillomavirus (HPV)-positive with either atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) of cervix. This study aimed to analyze the risk of developing a high-grade squamous intraepithelial lesion (HSIL) from either ASCUS or LSIL in HPV-positive women, so called ’progression’ rate, to investigate differences in the progression rates according to HPV type-specific infection, and to evaluate the various factors associated with the persistence or clearance of HPV infection in the Korean population. At present, the study protocol composed of cervical cytology, HPV DNA testing, and questionnaire have been conducted actively since the first participant was enrolled in 2010. This study is the first nationwide Korea HPV cohort study. Our data will provide valuable information about not only the ambiguous cytology results of ASCUS and LSIL but also the effect of the specific HPV type and other various factors on the progression to HSIL. Finally, the results of our study will be helpful and applicable to determine the primary cervical cancer prevention strategies.
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KEYWORD
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Cervical intraepithelial neoplasms, Cohort studies, Human papillomavirus, Uterine cervical neoplasms
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